Defining the human copper proteome and analysis of its expression variation in cancers.

@article{Blockhuys2017DefiningTH,
  title={Defining the human copper proteome and analysis of its expression variation in cancers.},
  author={St{\'e}phanie Blockhuys and Emanuele Celauro and Camilla Hildesj{\"o} and Amir Feizi and Olle St{\aa}l and Juan Carlos Fierro-Gonz{\'a}lez and Pernilla Wittung-Stafshede},
  journal={Metallomics : integrated biometal science},
  year={2017},
  volume={9 2},
  pages={
          112-123
        }
}
Copper (Cu) is essential for living organisms, and acts as a cofactor in many metabolic enzymes. To avoid the toxicity of free Cu, organisms have specific transport systems that 'chaperone' the metal to targets. Cancer progression is associated with increased cellular Cu concentrations, whereby proliferative immortality, angiogenesis and metastasis are… CONTINUE READING