Defining the heterochromatin localization and repression domains of SALL1.

  title={Defining the heterochromatin localization and repression domains of SALL1.},
  author={Christian Netzer and Stefan K Bohlander and Markus Hinzke and Yin Chen and Juergen Kohlhase},
  journal={Biochimica et biophysica acta},
  volume={1762 3},
SALL1 has been identified as one of four human homologues of the Drosophila region-specific homeotic gene spalt (sal), encoding zinc finger proteins of characteristic structure. Mutations of SALL1 on chromosome 16q12.1 cause Townes-Brocks syndrome (TBS, OMIM 107480). We have shown previously that SALL1 acts as a strong transcriptional repressor in mammalian cells when fused to a heterologous DNA-binding domain. Here, we report that SALL1 contains two repression domains, one located at the… CONTINUE READING

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