Defining the geometry of the two-component proteasome degron

  title={Defining the geometry of the two-component proteasome degron},
  author={Tomonao Inobe and Susan S Fishbain and Sumit Prakash and Andreas Matouschek},
  booktitle={Nature chemical biology},
The eukaryotic 26S proteasome controls cellular processes by degrading specific regulatory proteins. Most proteins are targeted for degradation by a signal or degron that consists of two parts: a proteasome-binding tag, typically covalently attached polyubiquitin chains, and an unstructured region that serves as the initiation region for proteasomal proteolysis. Here we have characterized how the arrangement of the two degron parts in a protein affects degradation. We found that a substrate is… CONTINUE READING

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