Defining the genomic landscape of head and neck cancers through next-generation sequencing.

@article{Rizzo2015DefiningTG,
  title={Defining the genomic landscape of head and neck cancers through next-generation sequencing.},
  author={Giananthony T Rizzo and Mik A. Black and Joe S. Mymryk and John W. Barrett and Anthony C Nichols},
  journal={Oral diseases},
  year={2015},
  volume={21 1},
  pages={
          e11-24
        }
}
Next-generation sequencing (NGS) has revolutionized the field of genomics and improved our understanding of cancer biology. Advances have been achieved by sequencing tumor DNA and using matched normal DNA to filter out germ line variants to identify cancer-specific changes. The identification of high incidences of activating mutations in head and neck squamous cell carcinoma (HNSCC) amenable to drug targeting has been made, with clear distinctions between the mutational profile of HPV-positive… CONTINUE READING
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