Defining the combinatorial space of PKC::CARD‐CC signal transduction nodes

  title={Defining the combinatorial space of PKC::CARD‐CC signal transduction nodes},
  author={Jens Staal and Yasmine Driege and Mira Haegman and Marja M Kreike and Styliani Iliaki and Domien Vanneste and Marie Lork and Inna S. Afonina and Harald Braun and Rudi Beyaert},
  journal={The FEBS Journal},
Signal transduction typically displays a so‐called bow‐tie topology: Multiple receptors lead to multiple cellular responses but the signals all pass through a narrow waist of central signaling nodes. One such signaling node for several inflammatory and oncogenic signaling pathways is the CARD‐CC/BCL10/MALT1 (CBM) complexes, which get activated by protein kinase C (PKC)‐mediated phosphorylation of the caspase activation and recruitment domain (CARD)‐coiled‐coil domain (CC) component. In humans… 
A nucleation barrier spring-loads the 1 CBM signalosome for binary activation 2 3
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Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain.
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The paracaspase MALT1 mediates CARD14‐induced signaling in keratinocytes
It is reported that in addition to NF‐κB signaling, CARD14 activates p38 and JNK MAP kinase pathways, all of which are dependent on the paracaspase MALT1, and this findings demonstrate a novel role for Malt1 in CARD14‐induced signaling and indicate MALT 1 as a valuable therapeutic target in psoriasis.
Protein kinase C in the immune system: from signalling to chromatin regulation
The role of PKCs as key cytoplasmic signal transducers in immune cell signalling, as well as its role in nuclear signal transduction is focused, and recent evidence for its newly discovered regulatory role in the nucleus as a chromatin‐associated kinase is highlighted.
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