Defining the combinatorial space of PKC::CARD‐CC signal transduction nodes

  title={Defining the combinatorial space of PKC::CARD‐CC signal transduction nodes},
  author={Jens Staal and Yasmine Driege and Mira Haegman and Marja M Kreike and Styliani Iliaki and Domien Vanneste and Marie Lork and Inna S. Afonina and Harald Braun and Rudi Beyaert},
  journal={The FEBS Journal},
Signal transduction typically displays a so‐called bow‐tie topology: Multiple receptors lead to multiple cellular responses but the signals all pass through a narrow waist of central signaling nodes. One such signaling node for several inflammatory and oncogenic signaling pathways is the CARD‐CC/BCL10/MALT1 (CBM) complexes, which get activated by protein kinase C (PKC)‐mediated phosphorylation of the caspase activation and recruitment domain (CARD)‐coiled‐coil domain (CC) component. In humans… 
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