Defining the clinical course of multiple sclerosis

  title={Defining the clinical course of multiple sclerosis},
  author={Fred D. Lublin and Stephen C. Reingold and Jeffrey A. Cohen and Gary R. Cutter and Per Soelberg S\orensen and Alan J. Thompson and Jerry S. Wolinsky and Laura Joan Balcer and Brenda Banwell and Frederik Barkhof and Bruce F. Bebo and Peter A. Calabresi and Michel C Clanet and Giancarlo Comi and Robert J Fox and M. S. Freedman and Andrew D. Goodman and Matilde Inglese and Ludwig Kappos and Bernd C. Kieseier and John A. Lincoln and Catherine Lubetzki and Aaron E. Miller and Xavier Montalban and P. W. O'Connor and John Petkau and Carlo Pozzilli and Richard A. Rudick and Maria Pia Sormani and Olaf St{\"u}ve and Emmanuelle L. Waubant and Chris H. Polman},
Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on a survey of international MS experts provided purely clinical phenotypes based on data and consensus at that time, but imaging and biological correlates were lacking. Increased understanding of MS and its pathology, coupled with general concern… CONTINUE READING

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