Defining the clinical course of multiple sclerosis

@article{Lublin1996DefiningTC,
  title={Defining the clinical course of multiple sclerosis},
  author={Fred D Lublin and Stephen C. Reingold},
  journal={Neurology},
  year={1996},
  volume={46},
  pages={907 - 911}
}
Standardization of terminology used to describe the pattern and course of MS is essential for mutual understanding between clinicians and investigators.It is particularly important in design of, and recruitment for, clinical trials statistically powered for expected outcomes for given patient populations with narrowly defined entry criteria. For agents that prove safe and effective for MS, knowledge of the patient populations in definitive clinical trials assists clinicians in determining who… 

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References

SHOWING 1-4 OF 4 REFERENCES
Severe nonfluency in aphasia. Role of the medial subcallosal fasciculus and other white matter pathways in recovery of spontaneous speech.
TLDR
It is suggested that one explanation for the more severe limitation in spontaneous speech in the first group is the extensive white matter lesion in these two subcortical pathways had interrupted a large number of connections for initiation and preparation of speech movements and limbic aspects of speech.
Duchenne muscular dystrophy
TLDR
It seems likely that, once the entire gene (cDNA) is available for screening, most DMD boys will show deletions, and the effort involved in screening all affected boys for deletions is considerably less.
Autosomal dominant cerebellar phenotypes
The dominantly inherited ataxias comprise a series of clinical phenotypes that include ataxia, dysarthria, dysmetria, and intention tremor resulting from the involvement of the cerebellum and its
The evolution of multiple sclerosis epidemiology