Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing

@inproceedings{Shnayder2018DefiningTT,
  title={Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing},
  author={Miri Shnayder and Aharon Nachshon and Benjamin Krishna and Emma J. Poole and Alina Boshkov and Amit Binyamin and Itay Maza and John Sinclair and Michal Schwartz and Noam Stern-Ginossar},
  booktitle={mBio},
  year={2018}
}
Primary infection with human cytomegalovirus (HCMV) results in a lifelong infection due to its ability to establish latent infection, with one characterized viral reservoir being hematopoietic cells. Although reactivation from latency causes serious disease in immunocompromised individuals, our molecular understanding of latency is limited. Here, we delineate viral gene expression during natural HCMV persistent infection by analyzing the massive transcriptome RNA sequencing (RNA-seq) atlas… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 33 times. VIEW TWEETS

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 70 references

Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency.

Proceedings of the National Academy of Sciences of the United States of America • 2017
View 4 Excerpts
Highly Influenced

SX, Single-Cell Transcriptomics of Latent HCMV ® March/April 2018 Volume 9 Issue 2 e00013-18 mbio.asm.org

N Stern-Ginossar, B Weisburd, +3 authors Huang
Science 338:1088 • 2012
View 7 Excerpts
Highly Influenced

High-resolution human cytomegalovirus transcriptome.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 6 Excerpts
Highly Influenced

Human cytomegalovirus gene expression during infection of primary hematopoietic progenitor cells: a model for latency.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…