Defining the Genomic Signature of Totipotency and Pluripotency during Early Human Development

@inproceedings{Galn2013DefiningTG,
  title={Defining the Genomic Signature of Totipotency and Pluripotency during Early Human Development},
  author={Amparo Gal{\'a}n and Patricia D{\'i}az-Gimeno and Mar{\'i}a Po{\'o} and Diana Valbuena and Eva Campelo S{\'a}nchez and Ver{\'o}nica Ruiz and Joaqu{\'i}n Dopazo and David Montaner and Ana Conesa and Carlos Sim{\'o}n},
  booktitle={PloS one},
  year={2013}
}
The genetic mechanisms governing human pre-implantation embryo development and the in vitro counterparts, human embryonic stem cells (hESCs), still remain incomplete. Previous global genome studies demonstrated that totipotent blastomeres from day-3 human embryos and pluripotent inner cell masses (ICMs) from blastocysts, display unique and differing transcriptomes. Nevertheless, comparative gene expression analysis has revealed that no significant differences exist between hESCs derived from… CONTINUE READING