Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity

@article{Knights2010DefiningTC,
  title={Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity},
  author={Kathleen M. Knights and Arduino Aleksander Mangoni and John O. Miners},
  journal={Expert Review of Clinical Pharmacology},
  year={2010},
  volume={3},
  pages={769 - 776}
}
The hypothesis that the anti-inflammatory activity of NSAIDs derives from COX inhibition is well established. It also underpins the accepted mechanism of the gastrointestinal and renal toxicity of NSAIDs. However, in terms of NSAID-induced cardiovascular toxicity, is COX inhibition then guilty by association? Multiple experimental models of COX-1/COX-2 inhibition have enabled ranking of the relative inhibitory activity of NSAIDs. Inhibition is expressed as an IC50 value and the index of COX… 
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