Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)

@article{Bernier2005DefiningRL,
  title={Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (\#22931) and RTOG (\# 9501)},
  author={Jacques Bernier and Jay Scott Cooper and Thomas F. Pajak and Martine van Glabbeke and Jean Bourhis and Arlene A. Forastiere and Esat Mahmut Ozsahin and John R. Jacobs and Jacek Jassem and Kie Kian Ang and Jean Louis Lefebvre},
  journal={Head \& Neck},
  year={2005},
  volume={27}
}
BACKGROUND In 2004, level I evidence was established for the postoperative adjuvant treatment of patients with selected high-risk locally advanced head and neck cancers, with the publication of the results of two trials conducted in Europe (European Organization Research and Treatment of Cancer; EORTC) and the United States (Radiation Therapy Oncology Group; RTOG. [] Key MethodRESULTS Extracapsular extension (ECE) and/or microscopically involved surgical margins were the only risk factors for which the…

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The introduction of immune checkpoint inhibitors to the therapeutic armamentarium for recurrent/metastatic head and neck cancer patients has led to clinical investigation of incorporation of PD-1 inhibition in the postoperative setting.

The addition of chemotherapy to adjuvant radiation is associated with inferior survival outcomes in intermediate‐risk HPV‐negative HNSCC

Only high‐risk tumors with extranodal extension (ENE) and/or positive surgical margins (PSM) benefit from adjuvant therapy (AT) with concurrent chemoradiation (CRT) compared to radiation therapy (RT)

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Preclinical work in signaling pathways and other oncogenic factors (e.g., human papillomavirus infection) will be the key to improving outcomes of head and neck cancer patients in the future.

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Level I evidence regarding improved efficacy in this setting for the concurrent administration of chemotherapy and radiotherapy is produced, and high-dose cisplatin and irradiation can now be considered the standard therapeutic approach for resected poor-risk disease.

Evolution of treatment and high-risk features in resectable locally advanced Head and Neck squamous cell carcinoma with special reference to extracapsular extension of nodal disease.

  • V. Krstevska
  • Medicine
    Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • 2015
It can be concluded that strong evidence exists for an improved outcome for high-risk resected patients treated with adjuvant CCRT, and Precise definition of the presence of ECE is highly recommended in order to provide proper selection of patients who would benefit from the postoperative C CRT.

ADJUVANT THERAPY FOR RESECTED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

Evidence supporting the role of adjuvant RT includes an analysis by the Surveillance, Epidemiology and End Results (SEER) program of node-positive head and neck cancer patients reporting an absolute 10% overall and cause-specific survival benefit at 5 years.

Systemic Treatment for Squamous Cell Carcinoma of the Head and Neck.

...

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