Defining peripheral nervous system dysfunction in the SOD-1G93A transgenic rat model of amyotrophic lateral sclerosis.

@article{Riva2014DefiningPN,
  title={Defining peripheral nervous system dysfunction in the SOD-1G93A transgenic rat model of amyotrophic lateral sclerosis.},
  author={Nilo Riva and Linda Chaabane and M Peviani and Daniela Ungaro and Teuta Domi and Giorgia Dina and Francesca Bianchi and Giorgia Spano and Federica Cerri and P. Podini and Massimo Corbo and Ubaldo Del Carro and Giancarlo Comi and Caterina Bendotti and Angelo Quattrini},
  journal={Journal of neuropathology and experimental neurology},
  year={2014},
  volume={73 7},
  pages={658-70}
}
Growing evidence indicates that alterations within the peripheral nervous system (PNS) are involved at an early stage in the amyotrophic lateral sclerosis (ALS) pathogenetic cascade. In this study, magnetic resonance imaging (MRI), neurophysiologic analyses, and histologic analyses were used to monitor the extent of PNS damage in the hSOD-1 ALS rat model. The imaging signature of the disease was defined using in vivo MRI of the sciatic nerve. Initial abnormalities were detected in the nerves by… CONTINUE READING