Defining neurotoxicity in a decision-making context.

  title={Defining neurotoxicity in a decision-making context.},
  author={Hugh A. Tilson and Robert C. Macphail and Kevin M. Crofton},
  volume={16 2},
Neurotoxicity is one of several noncancer endpoints used by regulatory agencies in risk assessment. At the US EPA, neurotoxicity is defined as an adverse change in the structure and/or function of the central and/or peripheral nervous system measured at the neurochemical, behavioral, neurophysiological or anatomical levels. Adverse effects include alterations that diminish an organism's ability to survive, reproduce or adapt to the environment. Generally, a weight-of-evidence approach is used… CONTINUE READING