Defining genomic alteration boundaries for a combined small cell and non-small cell lung carcinoma.

@article{Buys2009DefiningGA,
  title={Defining genomic alteration boundaries for a combined small cell and non-small cell lung carcinoma.},
  author={Timon P H Buys and Sarit Aviel-Ronen and Thomas K Waddell and Wan L. Lam and Ming-Sound Tsao},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2009},
  volume={4 2},
  pages={
          227-39
        }
}
In the rare case of a male patient presenting with a combined small cell lung carcinoma (SCLC), large cell neuroendocrine carcinoma and adenocarcinoma, we used whole genome analysis by tiling-path array comparative genomic hybridization to evaluate the clonal relationship between nodules. In two areas of SCLC distinguishable by divergent neuroendocrine marker expression (CD56 and chromogranin-A), the presence of identical genomic breakpoints and rearrangements indicated a common origin, with… CONTINUE READING
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