Defining genetic risk for graft-versus-host disease and mortality following allogeneic hematopoietic stem cell transplantation.

@article{Hansen2010DefiningGR,
  title={Defining genetic risk for graft-versus-host disease and mortality following allogeneic hematopoietic stem cell transplantation.},
  author={John A Hansen and Jason W Chien and Edus H Warren and Lue Ping Zhao and Paul J Martin},
  journal={Current opinion in hematology},
  year={2010},
  volume={17 6},
  pages={483-92}
}
PURPOSE OF REVIEW This review explores what is known about the genetics of hematopoietic stem cell transplantation (HCT) and how genetic polymorphism affects risk of graft-versus-host disease (GVHD) and mortality. RECENT FINDINGS Genetic variation found across the human genome can impact HCT outcome by causing genetic disparity between patient and donor and modifying gene function. Single nucleotide polymorphism (SNP) and structural variation can result in mismatching for cellular peptides… CONTINUE READING
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