Defining features of protective CD4 T cell responses to Mycobacterium tuberculosis.

@article{Sakai2014DefiningFO,
  title={Defining features of protective CD4 T cell responses to Mycobacterium tuberculosis.},
  author={Shunsuke Sakai and Katrin D Mayer-Barber and Daniel L Barber},
  journal={Current opinion in immunology},
  year={2014},
  volume={29},
  pages={
          137-42
        }
}
CD4 T cells are critical for control of Mycobacterium tuberculosis (Mtb) infection and represent the best hope for vaccine-elicited protection. However, little is understood about the properties of Mtb-specific CD4 T cells that mediate control, and the lack of correlates of protection present a significant barrier to the rational development of new vaccination and therapeutic strategies which are sorely needed. Here we discuss the features of protective CD4 T cells including recent evidence for… CONTINUE READING
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CD4+ T Cells: guardians of the phagosome.

  • Clinical microbiology reviews
  • 2014
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