Defining control coefficients in non-ideal metabolic pathways.

@article{Kholodenko1995DefiningCC,
  title={Defining control coefficients in non-ideal metabolic pathways.},
  author={Boris N. Kholodenko and David-P. Molenaar and Stefan Schuster and Reinhart Heinrich and Hans Victor Westerhoff},
  journal={Biophysical chemistry},
  year={1995},
  volume={56 3},
  pages={
          215-26
        }
}
The extent to which an enzyme controls a flux has been defined as the effect on that flux of a small modulation of the activity of that enzyme divided by the magnitude of the modulation. We here show that in pathways with metabolic channelling or high enzyme concentrations and conserved moieties involving both enzymic and non-enzymic species, this definition is ambiguous; the magnitude of the corresponding flux control coefficient depends on how the enzyme activity is modulated. This is… CONTINUE READING
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