Defining clinically meaningful change in health-related quality of life.

@article{Crosby2003DefiningCM,
  title={Defining clinically meaningful change in health-related quality of life.},
  author={Ross D. Crosby and Ronette L Kolotkin and Gordon Randall Williams},
  journal={Journal of clinical epidemiology},
  year={2003},
  volume={56 5},
  pages={
          395-407
        }
}
This article reviews current approaches to defining clinically meaningful change in health-related quality of life (HRQOL) and provides guidelines for their use. Definitions of clinically meaningful change are discussed. Two broad methods for identifying clinically meaningful change are contrasted: anchor-based methods and distribution-based methods. Anchor-based methods include cross-sectional approaches and longitudinal approaches. Distribution-based methods include those based on statistical… CONTINUE READING
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