Defining characteristics of Types I and II apoptotic cells in response to TRAIL.

@article{Ozren2002DefiningCO,
  title={Defining characteristics of Types I and II apoptotic cells in response to TRAIL.},
  author={Nesrin Oz{\"o}ren and Wafik S El-Deiry},
  journal={Neoplasia},
  year={2002},
  volume={4 6},
  pages={551-7}
}
Type I cells have been defined to be independent of mitochondria for the induction of Fas death receptor-mediated apoptosis, whereas Type II cells are mitochondria-dependent. Knock-out studies in mice show that thymocytes are Type I and liver cells are Type II. We have previously shown that primary human hepatocytes and HCT116 human colon carcinoma cells behave like Type II cells because TRAIL-induced apoptosis can be blocked by the caspase 9 inhibitor, Z-LEHD-FMK. On the other hand, caspase 9… CONTINUE READING
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