Defining antigen-dependent stages of T cell migration from the blood to the central nervous system parenchyma.

@article{Archambault2005DefiningAS,
  title={Defining antigen-dependent stages of T cell migration from the blood to the central nervous system parenchyma.},
  author={Angela S. Archambault and Julia E. Sim and Mary Ann T Gimenez and John H. Russell},
  journal={European journal of immunology},
  year={2005},
  volume={35 4},
  pages={1076-85}
}
In experimental autoimmune encephalomyelitis (EAE), intravenous transfer of activated CD4(+) myelin-specific T cells is sufficient to induce disease. Transferred T cells access the CNS parenchyma by trafficking across the blood brain barrier (BBB) vascular endothelium into the perivascular space, and then across the glial limitans that is made up of astrocytes and microglia. Flow cytometry analysis of cells isolated from CNS tissue does not distinguish between T cell populations at the various… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

T Cells—Protective or Pathogenic in Alzheimer’s Disease?

Journal of Neuroimmune Pharmacology • 2015
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…