Defining and assaying RNAi in mammalian cells.

  title={Defining and assaying RNAi in mammalian cells.},
  author={Konrad E. Huppi and Scott E. Martin and Natasha J. Caplen},
  journal={Molecular cell},
  volume={17 1},
The investigation of protein function through the inhibition of activity has been critical to our understanding of many normal and abnormal biological processes. Until recently, functional inhibition in biological systems has been induced using a variety of approaches including small molecule antagonists, antibodies, aptamers, ribozymes, antisense oligonucleotides or transcripts, morpholinos, dominant-negative mutants, and knockout transgenic animals. Although all of these approaches have made… CONTINUE READING

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