Corpus ID: 222090238

Defining and Estimating Subgroup Mediation Effects with Semi-Competing Risks Data

  title={Defining and Estimating Subgroup Mediation Effects with Semi-Competing Risks Data},
  author={Fei Gao and Fan Xia and Kwun Chuen Gary Chan},
  journal={arXiv: Methodology},
In many medical studies, an ultimate failure event such as death is likely to be affected by the occurrence and timing of other intermediate clinical events. Both event times are subject to censoring by loss-to-follow-up but the nonterminal event may further be censored by the occurrence of the primary outcome, but not vice versa. To study the effect of an intervention on both events, the intermediate event may be viewed as a mediator, but conventional definition of direct and indirect effects… Expand

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