Defining a new aggressiveness classification and using NFATc1 localization as a prognostic factor in cherubism.

@article{Kadlub2016DefiningAN,
  title={Defining a new aggressiveness classification and using NFATc1 localization as a prognostic factor in cherubism.},
  author={Natacha Kadlub and Quentin Sessiecq and Linda Dainese and Aline Joly and Daphn{\'e} Lehalle and Sandrine Marlin and C{\'e}cile Badoual and Louise Galmiche and Claire Majoufre-Lefebvre and Ariane Berdal and Marcel Deckert and M P Vazquez and Vianney Descroix and Am{\'e}lie E. Coudert and A Picard},
  journal={Human pathology},
  year={2016},
  volume={58},
  pages={62-71}
}
Cherubism is a rare genetic disease characterized by bilateral giant cell reparative granuloma of the jaws consisting of a fibrotic stroma with giant multinucleated cells (GMCs) and osteoclastic features. Cherubism severity is highly variable, and recurrence after surgery is the most important risk. Currently, there are no prognostic indicators. The aims of this study were to evaluate the osteoclastogenesis phenotype by histologic examination of nuclear factor of activated T cells 1 (NFATc1… CONTINUE READING