Defining Requirements for Collagenase Cleavage in Collagen Type III Using a Bacterial Collagen System*

@inproceedings{Yu2012DefiningRF,
  title={Defining Requirements for Collagenase Cleavage in Collagen Type III Using a Bacterial Collagen System*},
  author={Zhuoxin Yu and Robert Visse and M. Inouye and Hideaki Nagase and Barbara Brodsky},
  booktitle={The Journal of biological chemistry},
  year={2012}
}
Degradation of fibrillar collagens is important in many physiological and pathological events. These collagens are resistant to most proteases due to the tightly packed triple-helical structure, but are readily cleaved at a specific site by collagenases, selected members of the matrix metalloproteinases (MMPs). To investigate the structural requirements for collagenolysis, varying numbers of GXY triplets from human type III collagen around the collagenase cleavage site were inserted between two… CONTINUE READING
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