Defining Differential Genetic Signatures in CXCR4- and the CCR5-Utilizing HIV-1 Co-Linear Sequences

@inproceedings{Aiamkitsumrit2014DefiningDG,
  title={Defining Differential Genetic Signatures in CXCR4- and the CCR5-Utilizing HIV-1 Co-Linear Sequences},
  author={Benjamas Aiamkitsumrit and Will Dampier and Julio Mart{\'i}n-Garc{\'i}a and Michael R Nonnemacher and Vanessa Pirrone and Tatyana Ivanova Ivanova and Wen Zhong and Evelyn M Kilareski and Hazeez Aldigun and Brian Frantz and Matthew Rimbey and Adam Wojno and Shendra R Passic and Jean W. Williams and Sonia V Shah and Brandon Blakey and Nirzari Parikh and Jeffrey M. Jacobson and Brian Moldover and Brian Wigdahl and Fatah Kashanchi},
  booktitle={PloS one},
  year={2014}
}
The adaptation of human immunodeficiency virus type-1 (HIV-1) to an array of physiologic niches is advantaged by the plasticity of the viral genome, encoded proteins, and promoter. CXCR4-utilizing (X4) viruses preferentially, but not universally, infect CD4+ T cells, generating high levels of virus within activated HIV-1-infected T cells that can be detected in regional lymph nodes and peripheral blood. By comparison, the CCR5-utilizing (R5) viruses have a greater preference for cells of the… CONTINUE READING