Defining Conditions for Sustaining Epiblast Pluripotence Enables Direct Induction of Clinically-Suitable Human Myocardial Grafts from Biologics-Free Human Embryonic Stem Cells.

@article{Parsons2012DefiningCF,
  title={Defining Conditions for Sustaining Epiblast Pluripotence Enables Direct Induction of Clinically-Suitable Human Myocardial Grafts from Biologics-Free Human Embryonic Stem Cells.},
  author={James F. Parsons and David B. Smotrich and Rodolfo Gonz{\'a}lez and Evan Yale Snyder and Dennis A. Moore and Xuejun Huang Parsons},
  journal={Journal of clinical & experimental cardiology},
  year={2012},
  volume={S9}
}
To date, lacking of a clinically-suitable human cardiac cell source with adequate myocardium regenerative potential has been the major setback in regenerating the damaged human myocardium. Pluripotent Human Embryonic Stem Cells (hESCs) proffer unique revenue to generate a large supply of cardiac lineage-committed cells as human myocardial grafts for cell-based therapy. Due to the prevalence of heart disease worldwide and acute shortage of donor organs or human myocardial grafts, there is… CONTINUE READING