Defining Childhood Severe Falciparum Malaria for Intervention Studies

@article{Bejon2007DefiningCS,
  title={Defining Childhood Severe Falciparum Malaria for Intervention Studies},
  author={Philip Bejon and James Alexander Berkley and Tabitha Wanja Mwangi and Edna Adhiambo Ogada and Isaiah Njoroge Mwangi and Kathryn Maitland and Thomas N Williams and J Anthony G Scott and Mike English and Brett Lowe and Norbert Peshu and Charles R Newton and Kevin Marsh},
  journal={PLoS Medicine},
  year={2007},
  volume={4},
  pages={S1 - S90}
}
BACKGROUND Clinical trials of interventions designed to prevent severe falciparum malaria in children require a clear endpoint. The internationally accepted definition of severe malaria is sensitive, and appropriate for clinical purposes. However, this definition includes individuals with severe nonmalarial disease and coincident parasitaemia, so may lack specificity in vaccine trials. Although there is no "gold standard" individual test for severe malaria, malaria-attributable fractions (MAFs… CONTINUE READING

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