Defining AML and MDS second cancer risk dynamics after diagnoses of first cancers treated or not with radiation

@article{Radivoyevitch2016DefiningAA,
  title={Defining AML and MDS second cancer risk dynamics after diagnoses of first cancers treated or not with radiation},
  author={Tomas Radivoyevitch and Rainer K. Sachs and Robert Peter Gale and Remco J. Molenaar and David J. Brenner and Brian T Hill and Matt E. Kalaycio and Hetty E. Carraway and Sudipto Mukherjee and Mikkael A. Sekeres and Jaroslaw P. Maciejewski},
  journal={Leukemia},
  year={2016},
  volume={30},
  pages={285-294}
}
Risks of acute myeloid leukemia (AML) and/or myelodysplastic syndromes (MDS) are known to increase after cancer treatments. Their rise-and-fall dynamics and their associations with radiation have, however, not been fully characterized. To improve risk definition we developed SEERaBomb R software for Surveillance, Epidemiology and End Results second cancer analyses. Resulting high-resolution relative risk (RR) time courses were compared, where possible, to results of A-bomb survivor analyses. We… 
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58 Citations

Risk of subsequent myeloid neoplasms after radiotherapy treatment for a solid cancer among adults in the United States, 2000–2014

The findings support the importance of diagnostic precision in myeloid neoplasm classification since susceptibility following radiotherapy may vary by myelodysplasia-related changes, thereby informing risk/benefit discussions in first primary cancer treatment.

Sequential development of two separate therapy-related myeloid neoplasms following radiotherapy for prostate cancer

An extremely rare case with two separate t-MNs (therapy-related acute promyelocytic leukemia (t-APL) and t-MDS/AML) that sequentially developed following radiotherapy for prostate cancer that remained in complete remission for four years is reported.

Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma.

Role of radiotherapy and chemotherapy in the risk of leukemia after childhood cancer: An international pooled analysis

A pooled analysis of all published studies with detailed treatment data, including estimated active bone marrow dose received during radiation therapy and doses of specific chemotherapeutic agents for childhood cancer diagnosed from 1930 through 2000, found topoisomerase II inhibitors were associated with increased SPL risk.

Risk of developing chronic myeloid neoplasms in well-differentiated thyroid cancer patients treated with radioactive iodine

Data suggest that RAI treatment for WDTC is associated with increased risk of MDS with short latency and poor survival, and the increased risk was significantly associated with WDTC size ⩾2 cm or regional disease.

Risk of hematologic malignancies after breast ductal carcinoma in situ treatment with ionizing radiation

The data suggest that RT after breast conserving surgery for DCIS patients should be cautiously tailored, especially for low and intermediate-risk patients.

Risk of Hematologic Malignancies After Radioiodine Treatment of Well-Differentiated Thyroid Cancer.

RAI use in patients withWDTC should be limited to patients with high-risk disease features, and patients with WDTC treated with adjuvant RAI should be monitored for myeloid malignancies as part of cancer surveillance.

Association of Chemotherapy for Solid Tumors With Development of Therapy-Related Myelodysplastic Syndrome or Acute Myeloid Leukemia in the Modern Era

Large-scale, United States population-based data demonstrate excess tMDS/AML risks following chemotherapy for nearly all solid tumor types, consistent with expanded use of known leukemogenic agents in the 21st century.

Secondary malignancies in chronic myeloid leukemia patients after imatinib-based treatment: long-term observation in CML Study IV

The increased SIR for NHL has to be considered and long-term follow-up of CML patients is warranted, as the rate of secondary malignancies may increase over time.

The risk of developing acute non-lymphocytic leukemia in women with breast cancer

Breast cancer survivors have a higher risk of developing subsequent ANLL compared to the general population and increased vigilance should be shown towards the potential development of ANLL due to older age, larger tumor size, chemotherapy, and radiation exposure in survivors.
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