Defining 'chromosomal instability'.

  title={Defining 'chromosomal instability'.},
  author={J. Geigl and A. C. Obenauf and T. Schwarzbraun and M. Speicher},
  journal={Trends in genetics : TIG},
  volume={24 2},
  • J. Geigl, A. C. Obenauf, +1 author M. Speicher
  • Published 2008
  • Biology, Medicine
  • Trends in genetics : TIG
  • Most scientists agree that the majority of human solid malignant tumors are characterized by chromosomal instability (CIN) involving gain or loss of whole chromosomes or fractions of chromosomes. CIN is thought to be an early event during tumorigenesis and might therefore be involved in tumor initiation. Despite its frequent occurrence in tumors and its potential importance in tumor evolution, CIN is poorly defined and is used inconsistently and imprecisely. Here, we provide criteria to define… CONTINUE READING
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