Defined sequence modules and an architectural element cooperate to promote initiation at an ectopic mammalian chromosomal replication origin.

@article{Altman2004DefinedSM,
  title={Defined sequence modules and an architectural element cooperate to promote initiation at an ectopic mammalian chromosomal replication origin.},
  author={Amy L. Altman and Ellen Fanning},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 10},
  pages={
          4138-50
        }
}
A small DNA fragment containing the high-frequency initiation region (IR) ori-beta from the hamster dihydrofolate reductase locus functions as an independent replicator in ectopic locations in both hamster and human cells. Conversely, a fragment of the human lamin B2 locus containing the previously mapped IR serves as an independent replicator at ectopic chromosomal sites in hamster cells. At least four defined sequence elements are specifically required for full activity of ectopic ori-beta in… CONTINUE READING

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