Defined salt formulations for the growth of Salinispora tropica strain NPS21184 and the production of salinosporamide A (NPI-0052) and related analogs

@article{Tsueng2008DefinedSF,
  title={Defined salt formulations for the growth of Salinispora tropica strain NPS21184 and the production of salinosporamide A (NPI-0052) and related analogs},
  author={Ginger Tsueng and Sy Teisan and Kin Sing Lam},
  journal={Applied Microbiology and Biotechnology},
  year={2008},
  volume={78},
  pages={827-832}
}
Salinosporamide A (NPI-0052) is currently produced by a marine actinomycete, Salinispora tropica, via a saline fermentation process using a non-defined, commercially available synthetic sea salt, Instant Ocean. In order to control the consistency of the production of NPI-0052 and related analogs, two chemically defined salt formulations were developed to replace Instant Ocean. A chemically defined sodium-chloride-based salt formulation with similar sodium and chloride contents as in Instant… CONTINUE READING

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New salinosporamides from the marine actinomycete Salinispora tropica and thioester derivatives , potent inhibitors of 20 S proteasome

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