Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts.

@article{Mason2006DefinedGE,
  title={Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts.},
  author={Douglas X Mason and Daniel Keppler and Jun Zhang and Tonya J Jackson and Yvette R Seger and Seiichi Matsui and Fleurette W. Abreo and John K Cowell and Gregory J Hannon and Scott W Lowe and Athena Lin},
  journal={Carcinogenesis},
  year={2006},
  volume={27 2},
  pages={350-9}
}
In contrast to rodent cells, normal human fibroblasts are generally resistant to neoplastic transformation in vitro. Here, we report the derivation and characterization of a spontaneously transformed cell line from normal human IMR90 fibroblasts transduced with E1A and Ras oncogenes. Unlike the parental, non-tumorigenic E1A/Ras-expressing IMR90 cells, these spontaneously transformed cells displayed aberrant growth potential in vitro and were capable of tumorigenesis in vivo. In contrast to the… CONTINUE READING
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