Defined factors induce reprogramming of gastrointestinal cancer cells.

  title={Defined factors induce reprogramming of gastrointestinal cancer cells.},
  author={Norikatsu Miyoshi and Hideshi Ishii and Ken-ichi Nagai and Hiromitsu Hoshino and Koshi Mimori and Fumiaki Tanaka and Hiroaki Nagano and Mitsugu Sekimoto and Yuichiro Doki and Masaki Mori},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 1},
Although cancer is a disease with genetic and epigenetic origins, the possible effects of reprogramming by defined factors remain to be fully understood. We studied the effects of the induction or inhibition of cancer-related genes and immature status-related genes whose alterations have been reported in gastrointestinal cancer cells. Retroviral-mediated introduction of induced pluripotent stem (iPS) cell genes was necessary for inducing the expression of immature status-related proteins… CONTINUE READING


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