Defined MicroRNAs Induce Aspects of Maturation in Mouse and Human Embryonic-Stem-Cell-Derived Cardiomyocytes.

@article{Lee2015DefinedMI,
  title={Defined MicroRNAs Induce Aspects of Maturation in Mouse and Human Embryonic-Stem-Cell-Derived Cardiomyocytes.},
  author={Desy S. Lee and Jyh-Hong Chen and David J. Lundy and Chung-Hung Liu and S M Hwang and Lil M. Pabon and Ru-Chi Shieh and Chien-Chang Chen and Sheng-Nan Wu and Yu-Ting Yan and Sho-Tone Lee and Po-Ming Chiang and Shu Chien and Charles E Murry and Patrick Ching-Ho Hsieh},
  journal={Cell reports},
  year={2015},
  volume={12 12},
  pages={1960-7}
}
Pluripotent-cell-derived cardiomyocytes have great potential for use in research and medicine, but limitations in their maturity currently constrain their usefulness. Here, we report a method for improving features of maturation in murine and human embryonic-stem-cell-derived cardiomyocytes (m/hESC-CMs). We found that coculturing m/hESC-CMs with endothelial cells improves their maturity and upregulates several microRNAs. Delivering four of these microRNAs, miR-125b-5p, miR-199a-5p, miR-221, and… CONTINUE READING
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