Deficits in spontaneous burrowing behavior in the rat bilateral monosodium iodoacetate model of osteoarthritis: an objective measure of pain-related behavior and analgesic efficacy.

@article{Bryden2015DeficitsIS,
  title={Deficits in spontaneous burrowing behavior in the rat bilateral monosodium iodoacetate model of osteoarthritis: an objective measure of pain-related behavior and analgesic efficacy.},
  author={Luke A. Bryden and Janet R. Nicholson and Henri Dr. Doods and Anton Pekcec},
  journal={Osteoarthritis and cartilage},
  year={2015},
  volume={23 9},
  pages={
          1605-12
        }
}
OBJECTIVE To characterize deficits in burrowing behavior - an ethologically-relevant rodent behavior - in the monosodium iodoacetate (MIA) rat model of osteoarthritis (OA), and the sensitivity of these deficits to reversal by analgesic drugs of both prototypical and novel mechanisms of action. A second objective was to compare the burrowing assay to a spontaneous locomotor activity (sLA) assay. METHOD Male Wistar Han rats (200-220 g) received intrarticular (i.a.) injections of MIA or saline… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Similar Papers

Loading similar papers…