Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia.

@article{Strauss2011DeficitsIP,
  title={Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia.},
  author={Gregory P. Strauss and Michael J. Frank and James Waltz and Zuzana Kasanova and Ellen S. Herbener and James M. Gold},
  journal={Biological psychiatry},
  year={2011},
  volume={69 5},
  pages={424-31}
}
BACKGROUND Negative symptoms are core features of schizophrenia (SZ); however, the cognitive and neural basis for individual negative symptom domains remains unclear. Converging evidence suggests a role for striatal and prefrontal dopamine in reward learning and the exploration of actions that might produce outcomes that are better than the status quo. The current study examines whether deficits in reinforcement learning and uncertainty-driven exploration predict specific negative symptom… CONTINUE READING

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