Deficits in inhibition and flexibility are associated with the APOE-E4 allele in nondemented older adults.

@article{Wetter2005DeficitsII,
  title={Deficits in inhibition and flexibility are associated with the APOE-E4 allele in nondemented older adults.},
  author={Spencer R. Wetter and Dean C. Delis and Wes S. Houston and Mark W. Jacobson and Amy E. Lansing and Krystal R Cobell and David P. Salmon and Mark W. Bondi},
  journal={Journal of clinical and experimental neuropsychology},
  year={2005},
  volume={27 8},
  pages={
          943-52
        }
}
This prospective study of nondemented older adults at genetic risk for AD and other types of dementia (i.e., APOE e4 allele) utilized a new Stroop test that includes a dual executive-function condition requiring both response inhibition and cognitive switching. Results indicated that, relative to non-e4 subjects, the e4 group committed more errors, but only on the new Inhibition/Switching condition. In addition, error-rate variance on this task was more heterogeneous for the e4 compared to the… CONTINUE READING
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