Deficits in hippocampal-dependent transfer generalization learning accompany synaptic dysfunction in a mouse model of amyloidosis.

@article{Montgomery2016DeficitsIH,
  title={Deficits in hippocampal-dependent transfer generalization learning accompany synaptic dysfunction in a mouse model of amyloidosis.},
  author={Karienn Souza Montgomery and George S. Edwards and Yona R Levites and A. V. S. Sai. Kumar and Catherine Myers and Mark A. Gluck and Barry Setlow and Jennifer L. Bizon},
  journal={Hippocampus},
  year={2016},
  volume={26 4},
  pages={455-71}
}
Elevated β-amyloid and impaired synaptic function in hippocampus are among the earliest manifestations of Alzheimer's disease (AD). Most cognitive assessments employed in both humans and animal models, however, are insensitive to this early disease pathology. One critical aspect of hippocampal function is its role in episodic memory, which involves the… CONTINUE READING