Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI

Abstract

Mounting evidence implicates axonal transport defects, typified by the presence of axonal varicosities with aberrant accumulations of cargo, as an early event in Alzheimer's disease (AD) pathogenesis. Work identifying amyloid precursor protein (APP) as a vesicular motor receptor for anterograde axonal transport further implicates axonal transport in AD… (More)
DOI: 10.1016/j.neuroimage.2012.01.132

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Cite this paper

@article{Gallagher2012DeficitsIA, title={Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI}, author={Joseph J. Gallagher and Xiaowei Zhang and Gregory J. Ziomek and Russell E. Jacobs and Elaine L. Bearer}, journal={NeuroImage}, year={2012}, volume={60 3}, pages={1856-66} }