Deficits in a lateralized associative learning task in dopamine-depleted rats with functional recovery by dopamine-rich transplants.

@article{Dowd2004DeficitsIA,
  title={Deficits in a lateralized associative learning task in dopamine-depleted rats with functional recovery by dopamine-rich transplants.},
  author={Eil{\'i}s Dowd and Stephen B. Dunnett},
  journal={The European journal of neuroscience},
  year={2004},
  volume={20 7},
  pages={1953-9}
}
Experimental therapies for Parkinson's disease (PD) are commonly validated in unilateral animal models using simple tests of motor asymmetry such as rotation, stepping and cylinder tests. However, the human disorder is considerably more complex than this, and alternative tests that permit a more complete evaluation of the efficacy and mechanism of action of novel treatments are needed. In this study, an operant task that assesses the selection, initiation and execution of lateralized movements… CONTINUE READING

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