Deficit of [3H]L-689,560 binding to the glycine site of the glutamate/NMDA receptor in the brain in Huntington's disease.

@article{Reynolds1994DeficitO,
  title={Deficit of [3H]L-689,560 binding to the glycine site of the glutamate/NMDA receptor in the brain in Huntington's disease.},
  author={Gavin Paul Reynolds and Steven J. Pearson and Peter H. Hutson},
  journal={Journal of the neurological sciences},
  year={1994},
  volume={125 1},
  pages={46-9}
}
Binding of [3H]L-689,560 to the glycine site of the glutamate/NMDA receptor was carried out using post-mortem brain tissue from patients with Huntington's disease (HD) and from matched controls. Decreased binding site density (by 62% in the caudate nucleus, 20% in the frontal cortex) was identified in HD. The deficit found in the caudate nucleus in HD… CONTINUE READING