Deficit in nitric oxide production in cirrhotic rat livers is located in the sinusoidal and postsinusoidal areas.

@article{LoureiroSilva2003DeficitIN,
  title={Deficit in nitric oxide production in cirrhotic rat livers is located in the sinusoidal and postsinusoidal areas.},
  author={Maur{\'i}cio R Loureiro-Silva and Gregory W Cadelina and Roberto J. Groszmann},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2003},
  volume={284 4},
  pages={G567-74}
}
Intrahepatic nitric oxide (NO) production is decreased in cirrhotic livers. Our objective was to identify, in cirrhotic rat livers, intrahepatic vascular segments where the deficit of NO facilitates the effect of vasoconstrictors. By using a modified rat liver perfusion system with measurement of both the perfusion and sinusoidal (wedged hepatic vein) pressures, we studied the effect of the NO synthase blocker N(omega)-nitro-l-arginine (l-NNA) on the response to methoxamine (alpha(1… CONTINUE READING
22 Extracted Citations
39 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 22 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 39 references

Bioactivation of nitroglycerin and va G573 INTRAHEPATIC VASCULAR TONE MODULATION BY NITRIC OXIDE AJP-Gastrointest Liver Physiol

  • AA Dudenhoefer, MR Loureiro-Silva, GW Cadelina, T Gupta, RJ. Groszmann
  • APRIL
  • 2003
1 Excerpt

Portal hypertension

  • RJ Groszmann, R deFranchis
  • Schiff ’ s diseases of the liver ( 8 th ed…
  • 1999

Portal hypertension. In: Schiff’s diseases of the liver (8th ed.), edited by Schiff ER, Sorrell MF, and Maddrey WC

  • RJ Groszmann, R. de Franchis
  • 1999
2 Excerpts

Similar Papers

Loading similar papers…