Deficit in Selective and Divided Attention Associated with Cholinergic Basal Forebrain Immunotoxic Lesion Produced by 192-Saporin; Motoric/Sensory Deficit Associated with Purkinje Cell Immunotoxic Lesion Produced by OX7-Saporin

@article{Waite1999DeficitIS,
  title={Deficit in Selective and Divided Attention Associated with Cholinergic Basal Forebrain Immunotoxic Lesion Produced by 192-Saporin; Motoric/Sensory Deficit Associated with Purkinje Cell Immunotoxic Lesion Produced by OX7-Saporin},
  author={Jerene J. Waite and Marilyn Wardlow and Ann E. Power},
  journal={Neurobiology of Learning and Memory},
  year={1999},
  volume={71},
  pages={325-352}
}
The immunotoxin 192-saporin, infused intracerebroventricularly into rats, destroys cholinergic neurons in the basal forebrain nuclei. Doses required for complete cholinergic loss also kill some Purkinje cells. The immunotoxin OX7-saporin, when infused intraventricularly into rats, destroys Purkinje cells in a pattern similar to that produced by 192-saporin, without affecting cholinergic neurons. Thus, we used OX7-saporin to distinguish behavioral effects of 192-saporin due to cerebellar damage… CONTINUE READING

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