Deficient production of IL-1 receptor antagonist and IL-6 coupled to oxidative stress in cryopyrin-associated periodic syndrome monocytes.

@article{Carta2012DeficientPO,
  title={Deficient production of IL-1 receptor antagonist and IL-6 coupled to oxidative stress in cryopyrin-associated periodic syndrome monocytes.},
  author={Sonia Carta and Sara Tassi and Laura Delfino and Alessia Omenetti and Salvatore Raffa and Maria Rosaria Torrisi and Alberto Martini and Marco Gattorno and Anna Rubartelli},
  journal={Annals of the rheumatic diseases},
  year={2012},
  volume={71 9},
  pages={1577-81}
}
OBJECTIVE To determine whether dysregulated production of cytokines downstream of interleukin (IL)-1 participates in the pathophysiology of cryopyrin-associated periodic syndromes (CAPS). METHODS Primary monocytes from patients with CAPS, unstimulated or after stimulation with lipopolysaccharide (LPS) and other Toll-like receptor (TLR) agonists, were examined for signs of stress and production of IL-1β, IL-1 receptor antagonist (IL-1Ra) and IL-6 in comparison with monocytes from patients with… CONTINUE READING
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