Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotic patients.

  title={Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotic patients.},
  author={D. Slovik and J. Adams and R. Neer and M. Holick and J. Potts},
  journal={The New England journal of medicine},
  volume={305 7},
There is uncertainty about the adequacy of renal secretion of 1,25-dihydroxyvitamin D(1,25-(OH)2-D) in elderly patients with osteoporosis. To investigate this uncertainty, we stimulated secretion of 1,25-(OH)2-D with a 24-hour intravenous infusion of synthetic human parathyroid hormone fragment 1-34 and compared the results in normal young adults and elderly patients with untreated osteoporosis. Serum levels of 1,25-(OH)2-D were similar in both groups (49 +/- 10 and 42 +/- 9 pg per milliliter… Expand
Effect of aging on the metabolism of phosphorus and 1,25-dihydroxyvitamin D in healthy men.
In healthy elderly men in whom glomerular filtration rate is normal or near normal, serum concentrations of 1,25(OH)2D increase when dietary phosphorus is restricted; the magnitude of response at steady state is unaffected by aging, but the time course of response is delayed. Expand
Production and metabolic clearance of 1,25-dihydroxyvitamin D in men: effect of advancing age.
The results suggest that aging per se has little or no effect on the serum concentration, MCR, or production rate of 1,25-(OH)2D in men, however, maintenance of a normal production rate in elderly men may require increased circulating PTH. Expand
Low 1,25-dihydroxyvitamin D, secondary hyperparathyroidism, and normal osteocalcin in elderly subjects.
No compensatory increase in 1,25-dihydroxyvitamin D [1,25-(OH)2D] and no increase in osteocalcin in response to hypersecretion of PTH in the elderly suggest these 2 defects may contribute to the bone disease of the elderly. Expand
Abnormalities in parathyroid hormone secretion and 1,25-dihydroxyvitamin D3 formation in women with osteoporosis.
It is concluded that older women require a greater parathyroid hormone stimulus than younger women to maintain vitamin D homeostasis, because of an age-related decline in the formation of 1,25(OH)2D in response to parathyro hormone. Expand
Influence of age on effects of endogenous 1,25-dihydroxyvitamin D on calcium absorption in normal women
The data suggest that either elderly women have normal intestinal responsiveness to vitamin D or that the resistance to it is too mild to be detected by these methods. Expand
Decrease in bone level of 1,25-dihydroxyvitamin D in women over 45 years old
SummaryThe most active metabolite of vitamin D is 1,25-dihydroxyvitamin D [1,25(OH)2D]. Its level in the bone may play a role in the pathogenesis of metabolic bone diseases such as osteoporosis. ToExpand
Parathormone, calcitonin, and vitamin D metabolites during normal fracture healing in geriatric patients.
There were almost no changes in hormone serum levels during bone repair, except for a decrease in serum levels of 1,25(OH)2D from 25.3 +/-2.3 pg/ml on admission to 21.0 +/- 2.0 pg/ML eight weeks later (p less than .001). Expand
Reduced parathyroid hormone-stimulated 1,25-dihydroxyvitamin d production in vitamin d sufficient postmenoposual women with low bone mass and idiopathic secondary hyperparathyroidism.
  • E. Streeten, Amy S. Rogstad, +5 authors J. Shelton
  • Medicine
  • Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • 2013
Vitamin D sufficient patients who fit the criteria for EC-pHPT had reduced PTH-stimulated 1,25(OH)2D compared to controls, partially attributable to their higher BMI. Expand
Aging and renal responsiveness to parathyroid hormone in healthy men.
To determine whether aging impairs renal responsiveness to PTH, we studied the ability of the kidney to respond to infusion of human PTH-(1-34) for 24 h in 16 healthy men, 9 young (39 +/- 1 yr) and 7Expand
Changes in vitamin D metabolites during teriparatide treatment.
Treatment with teriparatide increases 1,25 dihydroxyvitamin D concentrations and decreases 25(OH)D concentrations, and the purpose of this study was to assess the changes in serum concentration of vitamin D metabolites during terIParatide 20 μg/day therapy in the double-blind Fracture Prevention Trial of postmenopausal women with osteoporosis and in the male study of men with osteopsorosis. Expand


Effect of Parathyroid Hormone on 1,25-Dihydroxyvitamin D Formation in Type I Pseudohypoparathyroidism
The role of parathyroid hormone (PTH) and cAMP in the hydroxylation of 25-hydroxyvitamin D to 1,25- dihydroxyvitamin D [1,25-(OH)2D] was explored in two young male volunteers and a patient withExpand
In normal volunteers infusion of parathyroid extract raised plasma 1,25-dihydroxyvitamin D (1,25-[OH]2D) levels by 80% (peak 8--40 h after infusion) without producing any significant change in plasmaExpand
The effects of oral CaCO3 loading and dietary calcium deprivation on plasma 1,25-dihydroxyvitamin D concentrations in healthy adults.
ABSTRACT Plasma 1,25-dihydroxyvitamin D [1,25(OH)2D] concentrations were observed to be inversely correlated with the urinary Ca/creatinine (r = –0.56) in 43 healthy adults eating ad libitum,Expand
Demonstration of a lack of change in serum 1 alpha,25-dihydroxyvitamin D in response to parathyroid extract in pseudohypoparathyroidism.
The results provide evidence that hypocalcemia in HP and PHP arises in part from low circulating 1 alpha,25-(OH)2D, and indicate that the lack of change in serum 1alpha,25(OH) 2D with PTE in patients with PHP is related to impaired renal adenylate cyclase and phosphaturic responses. Expand
Response of 1alpha,25-dihydroxyvitamin D3 to hypocalcemia in human subjects.
The relatively rapid response of 1alpha,25-dihydroxyvitamin D3 to hypocalcemia occurs with a time course consistent with regulation by parathyroid hormone and phosphate. Expand
The effect of age on calcium absorption and accumulation of 1,25-hydroxyvitamin D3 in intestinal mucosa of rats
Abstract Calcium transport in the proximal duodenum was measured in male rats of various ages by the everted intestinal sac method. Calcium transport markedly and progressively diminished from 54Expand
Effect of age on the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 by kidney of rat.
There is a marked decrease in the capacity of the vitamin D-deficient adult rat to convert 25-hydroxyvitamin D3 to 1,25-dihydroxyv vitamin D3, the physiologically active form of vitamin D. Expand
1,25-Dihydroxyvitamin D in biological fluids: a simplified and sensitive assay.
This assay shows that in the plasma of normal adult subjects there is a 1,25-(OH)2D concentration of 29 +/- 2 picograms per milliliter, while none can be detected in the Plasma of nephrectomized subjects and end-stage renal failure patients. Expand
Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium.
The data suggest that inadequate metabolism of 25-OH-D to 1,25(OH)(2)D contributes significantly to decreased calcium absorption and adaptation in both osteoporotic patients and elderly normal subjects. Expand
Adaptation of intestinal calcium absorption: parathyroid hormone and vitamin D metabolism.
It appears likely that the modulation of intestinal calcium absorption by dietary calcium is mediated by the parathyroid glands and the renal biogenesis of 1,25-dihydroxyvitamin D 3. Expand