Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism.

@article{Fuster2011DeficientPP,
  title={Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism.},
  author={Jose Javier Fuster and Herminia Gonz{\'a}lez-Navarro and {\'A}ngela Vinu{\'e} and Pedro Molina-S{\'a}nchez and Mar{\'i}a Jes{\'u}s Andr{\'e}s-Manzano and Keiichi I Nakayama and Antonio D{\'i}ez-Juan and Antonio Bernad and Cristina Rodr{\'i}guez and Jos{\'e} L Mart{\'i}nez-Gonz{\'a}lez and Vicente Andr{\'e}s},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 11},
  pages={2455-63}
}
OBJECTIVE Genetic ablation of the growth suppressor p27(Kip1) (p27) in the mouse aggravates atherosclerosis coinciding with enhanced arterial cell proliferation. However, it is unknown whether molecular mechanisms that limit p27's protective function contribute to atherosclerosis development and whether p27 exerts proliferation-independent activities in the arterial wall. This study aims to provide insight into both questions by investigating the role in atherosclerosis of p27 phosphorylation… CONTINUE READING

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