Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

  title={Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior},
  author={Yang Zhan and Rosa Chiara Paolicelli and Francesco Sforazzini and Laetitia Weinhard and Giulia Bolasco and Francesca Pagani and Alexei L Vyssotski and Angelo Bifone and Alessandro Gozzi and Davide Ragozzino and Cornelius Thilo Gross},
  journal={Nature Neuroscience},
Microglia are phagocytic cells that infiltrate the brain during development and have a role in the elimination of synapses during brain maturation. Changes in microglial morphology and gene expression have been associated with neurodevelopmental disorders. However, it remains unknown whether these changes are a primary cause or a secondary consequence of neuronal deficits. Here we tested whether a primary deficit in microglia was sufficient to induce some autism-related behavioral and… CONTINUE READING
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