Deficient major histocompatibility complex class II antigen presentation in a subset of Hodgkin's disease tumor cells.

@article{Bosshart1998DeficientMH,
  title={Deficient major histocompatibility complex class II antigen presentation in a subset of Hodgkin's disease tumor cells.},
  author={Herbert Bosshart and Ruth F. Jarrett},
  journal={Blood},
  year={1998},
  volume={92 7},
  pages={2252-9}
}
Hodgkin's disease is a common malignancy of the lymphoid system. Although the scarce Hodgkin and Reed-Sternberg (HRS) tumor cells in involved tissue synthesize major histocompatibility complex (MHC) class II and costimulatory molecules such as CD40 or CD86, it is unclear whether these tumor cells are operational antigen-presenting cells (APC). We developed an immunofluorescence-based assay to determine the number of MHC class II molecules present on the surface of single living HRS cells. We… CONTINUE READING
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