Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C beta4 mutant mice.

@article{Miyata2001DeficientLS,
  title={Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C beta4 mutant mice.},
  author={Mariko Miyata and Hyun Taek Kim and Koichi Hashimoto and Thomas K. M. Lee and Sang Yun Cho and Hongjian Jiang and Yan Wu and Kisun Jun and Dianqing Wu and Masanobu Kano and Ho Seob Shin},
  journal={The European journal of neuroscience},
  year={2001},
  volume={13 10},
  pages={1945-54}
}
Long-term depression (LTD) at parallel fibre-Purkinje cell synapse of the cerebellum is thought to be a cellular substrate for motor learning. LTD requires activation of metabotropic glutamate receptor subtype 1 (mGluR1) and its downstream signalling pathways, which invariably involves phospholipase Cbetas (PLCbetas). PLCbetas consist of four isoforms (PLCbeta1-4) among which PLCbeta4 is the major isoform in most Purkinje cells in the rostral cerebellum (lobule 1 to the rostral half of lobule 6… CONTINUE READING
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