Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

@article{Bourtchuladze1994DeficientLM,
  title={Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein},
  author={Roussoudan Bourtchuladze and Bruno G. Frenguelli and Julie A. Blendy and Diana Cioffi and G. Schutz and Alcino J. Silva},
  journal={Cell},
  year={1994},
  volume={79},
  pages={59-68}
}
The cAMP-responsive element-binding protein (CREB) has been implicated in the activation of protein synthesis required for long-term facilitation, a cellular model of memory in Aplysia. Our studies with fear conditioning and with the water maze show that mice with a targeted disruption of the alpha and delta isoforms of CREB are profoundly deficient in long-term memory. In contrast, short-term memory, lasting between 30 and 60 min, is normal. Consistent with models claiming a role for long-term… Expand
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